yap ihc Search Results


ihc analysis of yap, et a r, and et-1 protein expression  (Human Protein Atlas)
90
Human Protein Atlas ihc analysis of yap, et a r, and et-1 protein expression
Expression of <t>YAP</t> and ET-1/ET A R as a prognostic signature <t>in</t> <t>HG-SOC</t> patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack
Ihc Analysis Of Yap, Et A R, And Et 1 Protein Expression, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yap+ihc/ihc+analysis+of+yap++et+a+r++and+et+1+protein+expression/pmc06642155-362-3-21
Average 90 stars, based on 1 article reviews
ihc analysis of yap, et a r, and et-1 protein expression - by Bioz Stars, 2026-11
90/100 stars
  Buy from Supplier
ihc analysis of yap, etar, and et-1 protein expression  (Human Protein Atlas)
90
Human Protein Atlas ihc analysis of yap, etar, and et-1 protein expression
Expression of <t>YAP</t> and ET-1/ET A R as a prognostic signature <t>in</t> <t>HG-SOC</t> patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack
Ihc Analysis Of Yap, Etar, And Et 1 Protein Expression, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yap+ihc/ihc+analysis+of+yap++etar++and+et+1+protein+expression/pm31324767-373-7-19
Average 90 stars, based on 1 article reviews
ihc analysis of yap, etar, and et-1 protein expression - by Bioz Stars, 2026-11
90/100 stars
  Buy from Supplier
ihc analysis of yap  (Human Protein Atlas)
90
Human Protein Atlas ihc analysis of yap
Expression of <t>YAP</t> and ET-1/ET A R as a prognostic signature <t>in</t> <t>HG-SOC</t> patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack
Ihc Analysis Of Yap, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yap+ihc/ihc+analysis+of+yap/pmc06642155__41467_2019_11045_MOESM2_ESM-362-13-24
Average 90 stars, based on 1 article reviews
ihc analysis of yap - by Bioz Stars, 2026-11
90/100 stars
  Buy from Supplier

Image Search Results


Expression of YAP and ET-1/ET A R as a prognostic signature in HG-SOC patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack

Journal: Nature Communications

Article Title: β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

doi: 10.1038/s41467-019-11045-8

Figure Lengend Snippet: Expression of YAP and ET-1/ET A R as a prognostic signature in HG-SOC patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack

Article Snippet: IHC analysis of YAP, ET A R, and ET-1 protein expression in HG-SOC tissues and normal tissues was determined from the human protein atlas ( www.proteinatlas.org ) .

Techniques: Expressing, Control, Gene Expression, Activation Assay, Targeted Gene Expression